ea0016p624 | Reproduction | ECE2008
Wang Feng
, Wang Wei
, Wahala Kristiina
, Adlecreutz Herman
, Tikkanen Matti J
, Ikonen Elina
Background and aims: Dehydroepiandrosterone fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity. DHEA-FAEs function through hydrolysis of DHEA-FAEs into free DHEA and further metabolized to biologically active steroids. The lysosomal acid lipase (LAL) mediates the intracellular hydrolysis of cholesterol esters. This study aims to study the possible role of LAL on the hydrolys...